Winstrol Enanthate/Esterified Orals?

Q: I heard that an underground lab is working on stanozolol enanthate. This sounds crazy. I want to try it. But then I heard from another guy that it was impossible to put an ester on a methylated steroid, and even if you could, it would never come off— making the drug worthless. Is this true? I thought you would have a good answer for me.

A: No, this isn’t exactly true. While I’ve never seen stanozolol enanthate, I can tell you a little about esterification (the process of adding an ester to a steroid) and methylation (adding a methyl group). I trust you will find these are two very distinct technologies, applied for two very different purposes. Still, that doesn’t necessarily mean you cannot combine them. Let me explain.

Oral steroids are typically methylated (a methyl group has been added) at a position known as C-17-alpha. This addition accomplishes a number of things. Most basically, it prevents the 17-hydroxyl group (the active point of steroid attachment) from breaking down into a ketone by occupying one of the bonds needed to do this. This single reaction creates a steroid of extremely high oral bioavailability and resistance to metabolism. It also induces ‘steric hindrance’ toward the 17-beta hydroxyl group, which is a fancy way of saying that the methyl group interferes with metabolism of the 17-beta group by enzymes. This is another way the methyl modification intensifies steroid action.

Esterification, of course, is very different. Here, we are basically adding a long-chain fatty acid to the steroid molecule instead. It is added to the end of the active hydroxyl group at C-17 (beta). This is the same carbon atom, but in a different position. Esterification makes the drug more ‘fat like.’ Esterified steroids are more readily dissolved in oils than their base steroids, and leave the site of injection much more slowly because the environment of the body (blood) is water-based. With an enanthate steroid, it can take two to three weeks before the full dose hits the bloodstream. Once free in the blood, however, enzymes (esterase) will cleave off the fatty acid and leave the free active steroid to do its job.

So one modification makes an oral steroid more potent, while the other makes an injectable work longer. Can they be combined? Yes. From a chemistry standpoint, it is possible to have a methylated steroid that also has an ester on it. In fact, there is already an example of this called methandriol dipropionate. This steroid is methylated and esterified at the same time, and continues to work just fine. Some people have mistakenly assumed ‘steric hindrance’ means the ester cannot ever be broken off at all. This is not the case. It may slow this reaction slightly, but the ester bond will still break, and the free steroid will still make its way into the cells.

So why don’t we see more ‘dual’ steroids like methandriol? The answer is that the mixing of technologies serves no real function, and if anything, may create issues with the steroid. You see, methylated steroids can be liver toxic. This is a dose-dependent phenomenon, so you want to limit the dose to the point necessary for therapy, but not above— in a clinical setting, which all of these drugs are usually designed for. Esterified steroids like enanthate are very unbalanced in their delivery. You get a sharp spike in dosage for the first several days, which slowly declines. It does not distribute the drug steadily and evenly. This isn’t a big deal if the drug is not liver toxic. But if you did use stanozolol enanthate, your liver would have to process a high dose for a few days, then taper down. This variance in toxicity is not desirable at all. In fact, ester aside, you very rarely ever see Winstrol injections for use in humans for the same reason— only in animals.

Stanozolol enanthate has never been created and studied in a lab before, that I know of. So there is only so much I can tell you about its physical properties that isn’t speculation. I feel confident saying that it should work in an almost identical manner to the way injectable Winstrol does now (as the base steroid hasn’t changed), but would last longer. The dose will fluctuate a lot between applications though, and may cause elevated liver strain. I would guess one might be slightly more inclined to notice jaundice or other signs of toxicity, as you’d probably use higher total dosages to balance out the fluctuations. In short, I don’t see much advantage to creating this drug. But I would say that certainly, it is possible to create it.

Equipoise Pain

Q: I’ve used Equipoise in the past with no problem. This time I am experiencing a lot of pain, pretty much as bad as when I use testosterone propionate. I can barely move my leg. The dosage is 200 mg/mL. I know most EQ comes in dosages of 50 mg/mL. I’ve used both dosages before, though. Is it possible the concentration is too high and I am reacting to it this time? What is going on?

A: The pain could be caused by any number of things. To begin with, you mention the dosage is 200 mg/mL. This immediately tells me the product is most likely made by an underground lab. Up until a year or two ago, there was not a licensed facility anywhere in the world creating boldenone undecylenate beyond a dosage of 50 mg/mL. Presently, this dosage may be available by a limited number of international exporters and regional drug companies— a very limited number. A dosage of 200 mg/mL on the underground market, however, is highly common. So I am going to make this leap, which increases the possibilities greatly.

So what could be causing it? It could be so many things. Given that you’ve used EQ before at this dosage with no problem, I am inclined to think it is not a reaction to the drug itself, but something else in the product. The vial could be contaminated with something, such as heavy metals, dirty oil, free fatty acids, or even another steroid (maybe testosterone propionate, which is very cheap). It could have too much alcohol in it, which can be very irritating to muscle tissue. There could be bacteria in the vial, which might be causing infection at the site of application. There are many questions, and unfortunately no one simple answer. My advice to you would be to stop using the product. High pain already is a sign your body doesn’t like what it is using. Since there are so many other steroids out there, I’d suggest you find one you are comfortable with.

Transdermal Orals?

Q: What do you think about transdermal orals? Does this method remove the liver-toxicity of drugs like Dianabol and Anadrol?

A: Unfortunately, no. Transdermal application doesn’t eliminate the toxicity. Ultimately, all of the drug you administer to the body will need to be processed by the liver before it can be excreted. So there is no way to completely avoid toxicity. In theory, however, and I must emphasize the theory part, transdermal application might reduce the level of liver-toxicity by a small amount. It might do this by slowly and steadily delivering the drug to the liver for processing.

Normally, when an oral drug is taken, it is shuttled directly to the liver in one lump dose. Whatever gets through the liver the first time will slowly be processed on subsequent passes. Transdermal application avoids this first ‘bolus’ dose to the liver. But I am hesitant to even ascribe an advantage to this type of use. Remember, injectable versions of oral steroids do the exact same thing— avoid the first pass. But we have plenty of documented evidence that a drug like injectable Winstrol can produce the same issues of high liver-toxicity as the oral. So while it may be a little better, I definitely warn against any false sense of health security.

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