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Anabolic Freak Mar 2002 PDF Print E-mail
Written by Dave Palumbo   
Monday, 11 March 2002
 
I want to do a cycle of Primobolin because I heard the side effects are minimal and the muscle gains are permanent.  What’s the best form to take (injectable or pill)?  What kind of results can I expect with a 10-week cycle?

The anabolic steroid Primobolin (chemical name, methenolone) is found as either a long-acting injectable compound (primobolin depot) or as a fast-acting oral compound (primobolin acetate). Primobolin depot (methenolone enanthate), in men, should be injected two to three times per week at 100 milligrams per injection, so at least 200 milligrams is taken per week. This will ensure that adequate blood levels of the steroid have been achieved. Few or no deleterious side effects should be observed while taking Primobolin. In fact, users usually notice a strange feeling of well-being.
Primobolin acetate tabs (Primobolin S) have the unique nature of being orally active at high blood level concentrations without requiring the 17-alpha alkylated (toxic side chain that prolongs a drug’s half-life) chemical group attached to it. Primobolin acetate has an uncanny ability to avoid the liver (by "shortcutting" through the lymphatic system). Therefore, Primobolin tabs, while extremely potent, have virtually no toxicity associated with their use. The only drawback is an extremely short half-life, which necessitates that Primo tabs be taken every four to six hours (at 25mg per tab) to maintain high enough blood levels. As a result, most users combine the oral Primobolin tabs with the injectable Primobolin depot to create a somewhat stable blood concentration of the drug.
 
 
When is the best time of day to take my growth hormone injection? At first, I heard it should be taken before bed; then, I was told it should be taken in the middle of the night.  
 
  In search of the truth about the human body, I always go back to basic science. In this case, I’m referring to growth hormone secretion from the anterior pituitary gland. In the adolescent, GH is released in a very pulsatile manner (i.e., it’s secreted at various times throughout the day). The largest amount of growth hormone release has been measured exactly 90 minutes into the "deep sleep" phase of sleep.
This means the body produces the largest amount of growth hormone while sleeping; therefore, if you’re going to take some kind of supplement that stimulates GH release, the most prudent time would be before bed. However, when injecting actual growth hormone, the body's ability to secrete its own growth hormone becomes irrelevant because the amount of synthetic GH being injected into the body far outweighs any that’s naturally produced. Additionally, because our bodies actually produce a somewhat significant amount of growth hormone at night, the worst time to inject it would be at night because then the injected growth hormone would create a negative feedback signal that would, ultimately, shut down the body's natural production. 
 The most logical time to take growth hormone would be upon waking in the morning so the growth hormone and subsequent IGF-1 release from the liver will help "push" all the ingested morning "nutrients" into the new and recovering muscle cells. Additionally, the morning hours are when cortisol (the body's catabolic "nemesis") levels are highest. GH, in this instance, will help counteract some of these very catabolic processes.


 I competed in a local bodybuilding competition last year and to help me "dry out" before the show, I used the prescription diuretic Aldactone. I started taking it about four days out from the show on the advice of a guy at the gym. However, after the fourth day of   (i.e., the day of the contest), I began to get very "flat" looking and I began to cramp. Realizing that Aldactone was a potassium-sparing diuretic, I began to ingest sodium to try to counteract the extreme level of sodium depletion I was experiencing. However, nothing worked and my physique went downhill fast.  What did I do wrong?

 To properly answer your question, we must first explore exactly how the drug Aldactone exerts its diureses in the human body because, had you known that, you’d never have run into this problem. Aldactone is a competitive antagonist to the adrenally produced hormone aldosterone.  Aldosterone's job in the body is to maintain proper sodium balance (i.e., in the absence of the electrolyte, sodium, aldosterone will be secreted from the adrenal glands and will instruct the kidney tubules to reabsorb more sodium, thus restoring homeostasis in the body). When you began taking Aldactone four days out, you stifled your body's ability to reabsorb sodium. When, ultimately, you realized you had over-depleted your sodium reserves, it was impossible to restore the sodium balance (which would have filled out your flat muscles and negated the electrolyte-depleted cramps). 
You basically blew 16 weeks of dieting because you decided to listen to "some guy in the gym" rather than ask someone who had experience using diuretics. Someone "in the know” would have told you to stick to using a potassium-sparing diuretic like Dyazide that rids the body of sodium by directly influencing the kidneys to "dump" sodium. In this case, if too much Dyazide is consumed, extra sodium ingestion will cure the problem since the hormone aldosterone is functioning properly.

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