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What is the deal with all these new “legal” anti-estrogens? Are they really better than drugs like Nolvadex? 6-OXO (delta-4-1012-dimethyl-cyclopenta a phenantrene3617-trione) is ErgoPharm’s answer to estrogen annihilation. Until now, it has been the only true “legal” estrogen inhibitor. According to Patrick Arnold, “6-OXO binds to the aromatase enzyme in a permanent and irreversible manner, rendering it inactive. The result of this is an eventual diminishment of aromatase enzyme in the body and a concomitant reduction in estrogen levels.”Just recently, I got word from Bruce Kneller that two new “natural” anti-estrogens have hit the market:(1) 3-OHAT (3-hydroxyandrost-4-ene, 6,17-dione) is the active metabolite of 6-OXO. In other words, 6-OXO is a prohormone to 3-OHAT (similar to the way 1-AD is a prohormone to 1-testosterone). 3-OHAT binds to free aromatase enzyme and inactivates it.(2) ATD (1,4,6 -androstatriene, 3,17-dione) is a naturally occurring anti-aromatase that can be found in bile acids of cows. According to Kneller, “On paper, ATD is much more potent than 3-OHAT or 6-OXO. It has been well studied in mammals and is virtually non-toxic. It is also the anti-aromatase most often used by scientists in the lab.” ATD works by binding to the aromatase enzyme and killing it. To answer your question, since these new “legal” supplements actually inhibit the anti-aromatase enzyme system, they are far superior to Nolvadex (in men). Nolvadex only blocks estrogen receptors. It does nothing to stop the estrogen from being produced in the first place.There are two new products that contain both 3-OHAT and ATD in a patent-pending formula known as Dianestrozole. Gaspari Nutrition makes a product called Novedex Xtreme and KiloSports produces a similar product called Attack that both contain (as its active ingredient) this Dianestrozole formula. It seems that once all the prohormones are, officially, gone from the shelves, we might actually have a legal alternative to pursue— simply amazing!
I have several different kinds of drugs available to me. The problem is they are all oral compounds. I have Anavar, Winstrol, D-bol and Anadrol. What would be the best way to stack these drugs? Do all oral steroids have the same effects on the liver? Are some more toxic than others? I’ve heard that Anadrol is more liver toxic than Anavar, but I have also heard that all 17-alpha alkylated steroids are all the same. Please clarify.
Most oral anabolic steroids are 17-alpha alkylated. This added chemical group enables them to survive digestion by the liver. A few exceptions to the 17-alpha alkylated rule are Primobolin acetate tabs and Andriol (testosterone undecanoate) gel caps. And because they do not contain that particular chemical group, these compounds only last a few hours in the body (as opposed to the 24-hour lifespan of most 17-alpha alkylated steroids). The benefits of non- 17-alpha alkylated compounds are that they are virtually non-toxic to the liver. Is Anadrol more toxic than Anavar? You better believe it! Just because Anadrol, Anavar, Winstrol and Dianabol all are 17-alpha alkylated doesn’t mean they all possess the same toxicity levels. Likewise, just because they are all 17-alpha alkylated doesn’t mean they all possess the same anabolic properties. When stacking the above compounds, I would suggest combining a highly androgenic compound with a mildly androgenic, highly anabolic, compound. For example: Week 1-2: 50mg Anadrol per day and 15mg Anavar per day Week 3-4: 75mg Anadrol per day and 20mg Anavar per day Week 5-6: 100mg Anadrol per day and 25mg Anavar per day Week 7-8: 25mg Dianabol per day and 15mg Winstrol per day Week 9-10: 30mg Dianabol per day and 20mg Winstrol per day Week 11-12: 50mg Dianabol per day and 25mg Winstrol per day Week 13-16: 100mg Clomid every day
I’ve heard that GH has a negative effect on insulin sensitivity in the body. Aren't higher insulin levels, or at least better insulin sensitivity, supposed to help you add more muscle? If I’m using four IU of growth hormone every day in a bulking cycle, do you think it’s necessary to use insulin to get the most out of the GH?
Insulin is released from the beta cells of the pancreas in response to a rise in blood glucose (sugar) levels. Insulin, in turn, facilitates the transport of glucose into the cells of the body so it (glucose) can be used as an energy source in fueling cellular functions. Every cell in the body possesses receptors for insulin and it’s the number of insulin receptors that dictates how easily the body will be able to absorb sugar from the blood and move it into the cells. If the number of insulin receptors located on the cell membrane is low, we say that this cell is in a state of “insulin resistance.” The body’s first response to this situation is to release more insulin from the pancreas (thinking there is not enough insulin present). When insulin is over-secreted, the body has a much greater tendency to store calories as fat. Therefore, it’s very important for the body to be as receptive as possible to the insulin we do produce. Insulin sensitivity can be defined as: The number of insulin receptors that are available for shuttling glucose into the various cells throughout the body. Individuals who have numerous, responsive insulin receptors tend to under-secrete insulin and thus, tend to be leaner (low body fat) by nature, whereas individuals who are insulin resistant tend to over-secrete insulin and thus, tend to put on body fat more readily. People who fall into the first group (under-secreters) might find that by adding “small” amounts (two to four IU) of exogenous insulin (Humulin-R) to their daily regimens, they will increase the amount of lean muscle tissue they accrue since they will have a greater anabolic drive (more Amino Acids and glucose will be pushed into their very insulin-sensitive muscle cells).
On the other hand, people who fall into the second group (over-secreters) will benefit by taking supplements or drugs that increase insulin sensitivity (since they already have plenty of insulin present). One new drug, in particular, to recently hit the market is called Avandia (rosiglitazone maleate). Avandia improves glycemic (blood glucose) control while lowering circulating insulin levels. Therefore, it can restore an insulin resistant individual (someone with low insulin receptors and high insulin secretion) to a more normal, healthier, state in which they will maintain a leaner body composition while simultaneously possessing better control of blood glucose levels.
I have a problem that relates to Finaplex. No matter what conversion kit I use— even when everything is kept sterile— the day after I take my first injection I get severe heartburn and start burping up what smells like eggs; it’s disgusting. I even start to get bad stomach cramps followed by diarrhea. I wish I could use this stuff because I know it works well. Any suggestions? I know of only one other person who seems to have similar symptoms whenever he injects trenbolone (whether it’s made from the Finaplex pellets or it’s legitimately made by a company like Quality Vet). He, too, complains of diarrhea, fever and stomach upset. The following protocol that I suggested to him seems to have curtailed most of his negative side effects. Start off by injecting very small amounts of trenbolone (15 milligrams every other day) and as your body acclimates to it, progressively up the dose (by five milligrams per week). After seven or eight weeks, you should safely (and without nausea or diarrhea) be able to withstand 50 milligrams of trenbolone every other day. Let me know how it works out!
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