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Anabolic Freak August 2004 PDF Print E-mail
Written by Dave Palumbo   
Tuesday, 03 August 2004

 

I'm about to come off a cycle of 50 milligrams of trenbolone every other day (EOD) and 500  milligrams of Sustanon a week for 10 weeks. My supplier has sold me all legitimate stuff so far and told me he has liquid Clomid when I'm ready for it.  He is a personal friend and I don't think he would rip me off. However, I’ve never heard of Clomid in this form. Is this stuff real or should I have him get me the pill form?
           
The 500 milligrams of Sustanon per week and 50 milligrams of trenbolone EOD is a great 10-week cycle. You should see some good size and strength gains with minimal side effects. My experience in this industry with trusting “personal friends” has always proven to be a letdown. Invariably, this “good friend” has some “angle” and is just looking to make a quick dollar. If something sounds suspicious, and your gut feeling is telling you to leave it alone, I would suggest listening to your intuition. I’m actually surprised your “personal friend” didn’t try to tell you the all-too-familiar “Trust me, I got it tested!” story.
            As far as I know, there is no such thing as liquid Clomid. I’m not even sure the drug, clomiphene, is stable in a liquid medium. If I were you, I would stick to the old-fashioned Clomid pills. I am finishing a cycle of testosterone enanthate and Equipoise (EQ). I injected 500 milligrams of the testosterone and 100 milligrams of the EQ twice a week for 10 weeks. I gained 20 pounds over those 10 weeks.  My question is, when I come off all the gear, what natural supplements can I take to help kick-start my own testosterone production and keep my gains coming while training “naturally”?When attempting to rekindle your body’s natural muscle-building machinery, you have to attack the problem from four unique perspectives. First off, we want to wake up your sluggish pituitary gland (that has been asleep since you began taking exogenous testosterone injections) so it can begin to send out viable signals for your testicles to begin producing endogenous testosterone. Probably the best legal, herbal pituitary stimulant is Tribulus terrestris (which mimics the hypothalamic hormone gonadotropin releasing hormone— GnRH). When Tribulus exerts its effect, the pituitary in turn releases LH (luteinizing hormone), which ultimately induces the testicles to produce testosterone.            Secondly, another interesting point of attack would be on sex hormone binding globulin (SHBG). SHBG is a binding protein that circulates in the bloodstream looking for free molecules of testosterone to inactivate. The less testosterone that’s bound to SHBG (i.e., the more testosterone that’s in the “free” form), the greater the effectiveness of testosterone in the body (i.e., more muscle growth). The herbal extract stinging nettle has been shown to have some interesting effects on SHBG. When ingested in sufficient amounts, nettle binds to SHBG (similar to the way testosterone does) and it ties up a significant percentage of this circulating SHBG. The cumulative result is that less SHBG can bind to circulating testosterone and thus, a larger percentage of testosterone can now circulate in the “free” form and thus cause muscle growth and repair.            The third point of attack is to stifle the effects of estrogen in the body. By blocking the aromatization (or conversion) of testosterone into estrogen using a potent herb such as Chrysin, we can effectively enhance the amount of testosterone present for muscle building and diminish the amount of estrogen present (which could further suppress pituitary function, increase lower body fat deposition and increase edema or “bloating”). Likewise, we can flush extra estrogen out of the body altogether by introducing the supplement DIM (di-indolemethane) which has an extremely potent affect on removal of total body estrogen.            Finally, if we could amplify the levels of cAMP (also known as the Second Messenger) that ultimately reaches the nuclear receptor deep within the muscle cells, we could, in effect, increase the potency of the testosterone that actually reaches the receptors. In essence, we would be “recharging” the nuclear receptors of the muscle cells (something that’s the goal of every off-cycle bodybuilder). New research seems to indicate that herbs such as cordyceps sinensis, substrates such as NADH and essential fats such as flaxseed have a unique ability to amplify the testosterone signal (via increasing cAMP) at the muscle cell receptor sites. What exactly does all this mean? It is possible to achieve increased muscle gains while “off” all anabolic steroids!            This four-tiered attack on reestablishing the proper balance of testosterone in the body is, as far as I’m concerned, a new frontier in muscle growth and development. If we can gain control of the four variables I discussed above (whether you are a natural bodybuilder, an athlete “on” anabolic steroids, or a post-cycle bodybuilder trying restore the Natural Balance in your body), we should see new gains in muscular development like nothing ever witnessed before. 

            As for purchasing the above-mentioned herbs and supplements, the Internet is always a great place to start the search. However, I am by nature an extremely lazy individual and I would rather purchase a product that contains everything I need in one pill. While there are several companies out there that produce products aimed at boosting endogenous testosterone levels, the only product I know of that embraces all four areas I mentioned above is a new product called T-BOMB II by MHP (Maximum Human Performance). 

              Dave, I know this question is going to sound a bit high tech and very different from the usual anabolic steroid questions you receive. However, I know you have a diverse medical background and I figured you might be able to shed some insights. My sister is a type I diabetic and I have been reading about the possibility of stem cell transplants as a possible cure. I would love to see my sister be free of her multiple daily insulin shots. What’s the story with this new stem cell research?            In type I diabetes, the insulin-making beta cells are gradually destroyed, killed off by the patient's own immune system. Once they are gone, regular injections of insulin, which regulate blood sugar, are required.Stem cells are undifferentiated cells that can be induced to turn into any new cell type (assuming they are exposed to the correct inducing agent). To date, there are two types of stem cells— embryonic stems cells (found in the unborn fetus) and adult stem cells (found in various parts of the adult body).  According to a new Harvard University study, the growth and replacement of vital beta cells that make the insulin in the pancreas suggests the likely source of a diabetes cure will come from embryonic stem cells, not from adult stem cells.The researchers also found some evidence that insulin-making beta cells can renew themselves without new stem cells. This could someday offer a way to treat diabetes by replacing the cells killed off by the overactive immune system (i.e., assuming some of the beta cells survived).This might lead to a treatment for diabetes if it turns out that patients with insulin-dependent diabetes have beta cells remaining. If so, these might somehow be stimulated to grow. But, if all the original beta cells are gone, erased by the immune system, it means any replacement cells must come from embryonic stem cells and be implanted into the pancreas.            Dave, I just received my shipment of growth hormone (GH). I feel a little stupid asking you this question, but I was wondering how to measure International Units (IU) on an insulin syringe. My GH bottle says I have 10 milligrams of GH in each vial. If I add the 1mL of bacteriostatic water into the vial, how do I measure out 5IU GH?            Don’t feel stupid because this is probably one of the most frequently asked questions I receive from readers. First of all, it’s important to realize that insulin syringes are designed to measure insulin units (IU). Therefore, when you read the number “10” on an insulin syringe, it means 10 insulin units. Since insulin is found in a premixed form (and no reconstitution is necessary), it makes it very easy to measure insulin units (and that’s a good thing considering how many diabetics there are in the world). When measuring GH, the most important factor to consider is how much water you are adding to the lyophilized GH powder.            In your case, you’re adding 1mL of water to 10mg of GH. A simple conversion to remember is 1 mg of GH is equal to approximately 2.6IU GH; therefore, your 10mg vial of GH is actually 26IU of GH. 

When you add 1mL of water to the 10mg (26IU) of GH, each 0.10mL of water equals 2.6IU. To make things even easier, 0.10mL is the number “10” on the insulin syringe; therefore, if you were to draw out your GH to the “10” line (also the 0.10mL line), you would be taking 2.6IU of GH in each injection. In order to get 5IU of GH you would need to draw out 0.20mL (or the number “20” on the insulin syringe). This isn’t calculus; however, it can get a little confusing if you are not mathematically inclined. Take your time and ask questions!

 
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