Muscular Development Online Magazine - Eccentric Exercise Increases Genes for Inflammation

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Eccentric Exercise Increases Genes for Inflammation

Written by Robbie Durand

Monday, 07 April 2008

Eccentric exercise is a potent stimulator of muscle hypertrophy. Muscle inflammation is a crucial step in the hypertrophy process yet little is known about gene responses for inflammation after exercise. Subjects performed 2 bouts of maximal eccentric exercise while muscle biopsies were taken 6 hours after exercise. Genes for muscle inflammation were assessed during the recovery period for exercise. MCP-1, a secreted inflammatory chemokine that signals monocytes was significantly elevated between the leg that performed eccentric contractions following the first exercise bout (9.2 fold change) and was subsequently significantly elevated even more in the eccentric leg

between bouts (2.6 fold change from bout 1 to bout 2). Increased MCP-1 expression has been widely associated with the inflammatory pathologies, and studies have demonstrated that MCP-1's primary role is to recruit macrophages to sites of injury or infection. Recent studies suggest that the MCP-1 response involves both macrophages and satellite cells, both of which play important roles in muscle regeneration after injury. Researchers also found that there were a greater percentage of satellite cells expressing MCP-1 following the second bout (54%) as compared to the first bout (29%) in the ECC leg, suggesting that satellite cells may be either "primed" to make MCP-1 protein attracted to the satellite cells.

Hubal MJ, Chen TC, Thompson PD, Clarkson PM. Inflammatory gene changes

associated with the repeated bout effect. Am J Physiol Regul Integr Comp Physiol. 2008 Mar

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