A number of studies in both humans and animals have shown that testosterone treatment increases
muscle fiber diameter, the number of myonuclei present in muscle fibers,
the absolute number of satellite cells and the percentage
of satellite cells relative to myofiber. Most bodybuilders realize that estrogen must be reduced
during cycles, but completely blocking the actions of estrogen may not be a good thing.
Combined estrogen/androgen implants are more
effective than either androgens or estrogens alone in stimulating muscle growth.
In the journal of Domestic Animal Endocrinology researchers reported that both estrogens and
androgens enhance satellite cell activity in bulls. Treatment of satellite cell cultures
with either estrogen or testosterone resulted in a
concentration-dependent, threefold, increase in IGFI mRNA expression. I consulted
Dave Palumbo on this study and he agrees that complete suppression of estrogen can hinder
muscle mass gains; the key to muscle growth
is to minimize estrogen not completely eliminate estrogen.
Kamanga-Sollo E, White ME, Hathaway MR, Chung KY, Johnson BJ, Dayton WR.
Roles of IGF-I and the estrogen, androgen and IGF-I receptors in
estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine
satellite cells. Domest Anim Endocrinol. 2008
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