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Testosterone and Fat Loss- Greater Benefits Than Realized |
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Written by Dan Gwartney, MD
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Sunday, 04 January 2009 |
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Page 5 of 5
Greater Benefits Than Realized
The field of study remains wide open, but the interesting studies noted above strongly support the idea of anabolic steroids having direct effects on fat loss. Considering the diverse effects of testosterone and the obvious differences between men and women, it’s not surprising to learn of this potential. The greatest clinical promise for these findings lies with the aging population, as they suffer from age-related declines in many hormones.22 It’s likely that pharmaceutical companies will attempt to develop specific steroids or steroid-like molecules to take advantage of the fat reducing effects noted. By increasing the rate at which fat is released from fat cells, preventing the development of new fat cells and increasing the metabolic rate through the growth of muscle and lean mass, anabolic steroids may offer even greater benefits than have been realized to date.
References:
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19. Pedersen SB, Kristensen K, et al. Estrogen controls lipolysis by up-regulating ?2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor ?. Implications for the female fat distribution. J Clin Endocrinol Metab, 2004;89:1869-78.
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21. Dieudonne MN, Pecquery R, et al. Opposite effects of androgens and estrogens on adipogenesis in rat preadipocytes: evidence for sex and site-related specificities and possible involvement of insulin-like growth factor 1 receptor and peroxisome proliferator-activated receptor gamma2. Endocrinology, 2000;141:649-56.
22. Vermeulen A, Goemaere S, et al. Testosterone, body composition and aging. J Endocrinol Invest, 1999;22:110-6.
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