|
Page 4 of 4
Eat Your Veggies!!
Bodybuilding is a way of life, eating a high protein/high fat rich in sodium chloride without vegetables can cause a chronic state of mild acidosis. I am not condoning a vegetarian diet, but based on the new research eating vegetables with your high protein meals can neutralize the acidity and result in a more alkaline state. The blood is supposed to be slightly alkaline, yet modern western diets promotes acidosis which causes muscle protein loss, both by enhancing protein degradation and by inhibiting protein synthesis. This evidence suggests that maintenance of normal pH will help to preserve muscle mass and thereby improves health. Modifying the effect of dietary sodium chloride and potassium-base can prevent the age-related decline in muscle mass, kidney stones, and perhaps age related decline in renal function. Re-exchanging the NaCl in our present diet for the potassium-base that our ancestral species ate in abundance can be shown to correct diet-induced low-grade metabolic acidosis, and the consequent biochemical evidences of decreased growth hormone secretion, and increased protein catabolism. Beyond that, the supplementation of the diet with potassium-base can override the effects of NaCl loading on blood pressure and urinary calcium excretion. Thus, increasing dietary potassium-base to levels approaching those of our stone-age forebears, either with fruits and non-grain plant foods, or with supplemental potassium-base, would seem to hold particular promise for preventing or delaying expression of these age- and diet-related diseases and their consequences.
•Ø The best way to get adequate potassium in the diet is not through supplements or vitamins. Eating a wide variety of healthy foods that contain potassium is usually the best. Consuming too much potassium may lead to heart problems and or death.
•Ø Adding avocados and almonds which are alkaline will decrease the acid load of a meal.
•Ø Add Supplemental Glutamine - glutamine supplementation has been shown to neutralize acids. Interestingly, during metabolic acidosis intestinal glutamine uptake is increased, which shows the body is trying to increase its glutamine content in order to correct its acid imbalance.
•Ø Add Sodium Bicarbonate (Baking Soda) To Your Workout Shake - sodium bicarbonate is a great buffering agent and may also increase Athletic Performance.
Key Points:
- A high protein/high fat diet without vegetables can result in a mild chronic acidosis.
- Sodium Chloride consumption is associated with increased acidosis.
- Acidosis has been shown to increase muscle tissue breakdown.
- Supplementation with potassium/sodium bicarbonate/glutamine will neutralize blood pH.
- Greenhaff PL, Gleeson M, Maughan RJ. The effects of dietary manipulation on blood acid-base status and the performance of high intensity exercise. Eur J Appl Physiol Occup Physiol. 1987;56(3):331-7.
- Dawson-Hughes B, Harris SS, Ceglia L. Alkaline diets favor lean tissue mass in older adults. Am J Clin Nutr. 2008 Mar;87(3):662-5.
- Ball D, Greenhaff PL, Maughan RJ. The acute reversal of a diet-induced metabolic acidosis does not restore endurance capacity during high-intensity exercise in man. Eur J Appl Physiol Occup Physiol. 1996;73(1-2):105-12.
- Ballmer PE, McNurlan MA, Hulter HN, et al. Chronic metabolic acidosis decreases albumin synthesis and induces negative nitrogen balance in humans. J Clin Invest 1995; 95:39-45.
- May RC, Masud T, Logue B, et al. Chronic metabolic acidosis accelerates whole body proteolysis and oxidation in awake rats. Kidney Int 1992; 41:1535-1542.
- May RC, Masud T, Logue B, et al. Metabolic acidosis accelerates whole body protein degradation and leucine oxidation by a glucocorticoid dependent mechanism. Miner Electrolyte Metab 1992; 18:245-249.
- May RC, Bailey JL, Mitch WE, et al. Glucocorticoids and acidosis stimulate protein and amino acid catabolism in vivo. Kidney Int 1996; 49:679-683.
- Reaich D, Channon SM, Scrimgeour CM, Goodship TH. Ammonium chloride-induced acidosis increases protein breakdown and amino acid oxidation in humans. Am J Physiol 1992; 263:735-739.
- Reaich D, Channon SM, Scrimgeour CM, et al. Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation. Am J Physiol 1993; 265:230-235.
- Mitch WE, Goldberg AL. Mechanisms of muscle wasting: the role of the ubiquitin-proteasome pathway. N Engl J Med 1996; 335:1897-1905.
- Isozaki U, Mitch WE, England BK, Price SR. Protein degradation and increased mRNAs encoding proteins of the ubiquitin-proteasome proteolytic pathway in BC3H1 myocytes require an interaction between glucocorticoids and acidification. Proc Natl Acad Sci U S A 1996; 93:1967-1971.
- England BK, Chastain JL, Mitch WE. Abnormalities in protein synthesis and degradation induced by extracellular pH in BC3H1 myocytes. Am J Physiol 1991; 260:277-282.
- Vosswinkel JA, Brathwaite CE, Smith TR, et al. Hyperventilation increases muscle protein synthesis in critically ill trauma patients. J Surg Res 2000; 91:61-64.
- Frassetto L, Sebastian A. 1996 Age and systemic acid-base equilibrium: analysis of published data. J Gerontol. 51A:B91-B99.
- Frassetto L, Morris Jr RC, Sebastian A. 1996 Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline. Am J Physiol. 271:1114-1122.
- Frassetto L, Morris RC Jr, Sebastian A. Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women. J Clin Endocrinol Metab. 1997 Jan;82(1):254-9.
- Frassetto L, Morris RC Jr, Sellmeyer DE, Todd K, Sebastian A. Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. Eur J Nutr. 2001 Oct;40(5):200-13. Review.
- Garibotto G, Russo R, Sofia A, Sala MR, Sabatino C, Moscatelli P, Deferrari G, Tizianello A (1996) Muscle protein turnover in chronic renal failure patients with metabolic acidosis or normal acid-base balance. Miner Electrolyte Metab 22:58-61
- May RC, Kelly RA, Mitch WE (1986) Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid- dependent mechanism. J Clin Invest 77:614-621
- Williams B, Layward E, Walls J (1991) Skeletal muscle degradation and nitrogen wasting in rats with chronic metabolic acidosis. Clin Sci 80:457-462
- Frassetto L, Morris RC, Jr., Sebastian A (1997) Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women. J Clin Endocrinol Metab 82:254-259.
- Mitch WE, Price SR. Mechanisms activating proteolysis to cause muscle atrophy in catabolic conditions. J Ren Nutr. 2003 Apr;13(2):149-52. Review.
- Mardon J, Habauzit V, Trzeciakiewicz A, Davicco MJ, Lebecque P, Mercier S, Tressol JC, Horcajada MN, Demigné C, Coxam V. Long-term intake of a high-protein diet with or without potassium citrate modulates acid-base metabolism, but not bone status, in male rats. J Nutr. 2008 Apr;138(4):718-24.
- Bailey JL, Wang X, England BK, Price SR, Ding X, Mitch WE. The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway. J Clin Invest. 1996 Mar 15;97(6):1447-53.
- Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC Jr. Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors. Am J Clin Nutr. 2002 Dec;76(6):1308-16.
- Scheingraber S, Rehm M, Sehmisch C, Finsterer U. Rapid saline infusion produces hyperchloremic acidosis in patients undergoing gynecologic surgery. Anesthesiology 90: 1265-1270, 1999.
- Frassetto LA, Morris RC Jr, Sebastian A. Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet. Am J Physiol Renal Physiol. 2007 Aug;293(2):F521-5.
|