Dr. Jekyll was a brilliant medical researcher who was on a quest to discover the biochemical pathways that make men become evil. Using himself as a test subject for his own secret serum, Dr. Jekyll developed a potion that when ingested, enabled him to metaphysically transform into Edward Hyde. As Hyde, Dr. Jekyll's evil side was completely manifested in body, mind and spirit. He was taller, more powerfully built and therefore stronger and hideously ugly, looking more Neanderthal man than the venerable Dr. Jekyll. Mr. Hyde possessed superhuman strength, dense muscle tissue and had high resistance to injury, which allowed him to achieve his darkest desires.
The transformation serum is a real-life occurrence that takes place for all bodybuilders who want to make it to the top. They use their bodies as their laboratories, trying the newest substances medical science has to offer to create the perfect monster…bigger and stronger. This is the quest for every bodybuilder on the planet— to find the magic ingredient that transforms them into a heavily muscled monster! Well, a new substance called Mechano Growth Factor (MGF) may be just the thing in the near future to make testosterone the next-best choice in anabolics.

IGF-1 Increases Muscle Hypertrophy Through Satellite Cell Activation

Insulin-like growth factor (IGF-1) is produced by the liver and induced by growth hormone. IGF-1 is a main regulator of muscle tissue mass and is known to play an important role in the muscle hypertrophy adaptations to muscle overload. Over the years, researchers have discovered that IGF-1 isn’t only produced in the liver, but is produced directly within muscle.
Previous research indicates that IGF-1 is involved in the maintenance of skeletal muscle tissue and also in the prevention of cell death and is an important regulator of protein synthesis.1,2 IGF-1 has a critical role in the activation of satellite cells or muscle stem cells that are required for local tissue repair after exercise. Satellite cells normally just lay around muscle fibers quietly until they become activated and fuse with muscle fibers. Muscle-fiber damage induced by heavy resistance exercise seems to have potent effects on activating satellite cells, in that satellite cells become activated and fuse with the damaged muscle fibers, causing muscle hypertrophy.4

It's also interesting to note that with aging, there’s a loss of skeletal muscle mass and regenerative capacity. The reduced capacity to regenerate older muscle seems to be due to the decreased ability to activate satellite cells.5 Satellite cells are so important for muscle repair and growth that if you destroy satellite cells through gamma irradiation, you can overload muscle and no growth occurs.3 Muscle gene expression of IGF-1 increases dramatically after muscle overload, even if there’s no GH being produced, as patients with GH deficiency can still increase IGF-1 levels in muscle after muscle overload.18