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Crank Up those Catecholamines for Fat Loss!! |
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Written by Robbie Durand
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Thursday, 29 January 2009 |
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Page 5 of 5
On adipose cells, drugs that stimulate ? receptors enhance fat loss. Most thermogenic supplements on the market target fat cells by stimulating the production of catecholamines, norepinephrine and epinephrine. Researchers have discovered that if adipose cells are exposed to norepinephrine, fat cells won't proliferate and form new fat cells. But if the fat cells are exposed to drugs like propranolol, which blocks the actions of norepinephrine, new fat cells are created.15
Trying to get ripped for a competition or for personal goals can be an extremely difficult feat to accomplish. Everyone wants to have that ripped look where your skin is paper-thin and veins pop out everywhere, but achieving that look takes an extreme amount of willpower, guts and dedication in the gym. Your body doesn’t understand the mind of a bodybuilder so it thinks, “I’m starving, there’s a drought, calories are insufficient, I’m losing body fat…slow down all metabolic systems until body fat returns to normal.” Your own body tries to sabotage your competition goals of losing fat by slowing down your metabolism and breaking down lean muscle mass as an energy source. During a calorie-restricted diet the sympathetic nervous system is decreased. This decrease in sympathetic nerve activity results in a reduction in lower metabolic rate, thus conserving reserves of nutrients. During fasting or calorie restriction, adipose tissue readily releases stored energy. That’s where thermogenic supplements come in handy because they increase sympathetic nervous system activity and restore sympathetic tone.
References:
1. Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, Wolfe RR. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol, 1993 Sep;265(3 Pt 1):E380-91.
2. Mora-Rodriguez R, Coyle EF. Effects of plasma epinephrine on fat metabolism during exercise: interactions with exercise intensity. Am J Physiol Endocrinol Metab, 2000 Apr;278(4):E669-76.
3. Langfort J, Ploug T, Ihlemann J, Enevoldsen LH, Stallknecht B, Saldo M, Kjaer M, Holm C, Galbo H. Hormone-sensitive lipase (HSL) expression and regulation in skeletal muscle. Adv Exp Med Biol, 1998;441:219-28. Review.
4. Kjaer M, Howlett K, Langfort J, Zimmerman-Belsing T, Lorentsen J, Bulow J, Ihlemann J, Feldt-Rasmussen U, Galbo H. Adrenaline and glycogenolysis in skeletal muscle during exercise: a study in adrenalectomised humans. J Physio, 2000 Oct 15;528 Pt 2:371-8.
5. Watt MJ, Stellingwerff T, Heigenhauser GJ, Spriet LL. Effects of plasma adrenaline on hormone-sensitive lipase at rest and during moderate exercise in human skeletal muscle. J Physiol, 2003 Jul 1;550(Pt 1):325-32.
6. Cousin B, Casteilla L, Lafontan M, Ambid L, Langin D, Berthault MF, Penicaud L. Local sympathetic denervation of white adipose tissue in rats induces preadipocyte proliferation without noticeable changes in metabolism. Endocrinology, 1993 Nov;133(5):2255-62.
7. Wahrenberg H, Lonnqvist F, Arner P. Mechanisms underlying regional differences in lipolysis in human adipose tissue. J Clin Invest, 1989 Aug;84(2):458-67.
8. Kraemer FB, Shen WJ. Hormone-sensitive lipase knockouts. Nutr Metab (Lond), 2006 Feb 10;3:12.
9. Large V, Reynisdottir S, Langin D, Fredby K, Klannemark M, Holm C, Arner P. Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat cells of obese subjects. J Lipid Res, 1999 Nov;40(11):2059-66.
10. Hoffstedt J, Arner P, Schalling M, Pedersen NL, Sengul S, Ahlberg S, Iliadou A, Lavebratt C. A common hormone-sensitive lipase i6 gene polymorphism is associated with decreased human adipocyte lipolytic function. Diabetes, 2001 Oct;50(10):2410-3.
11. Reynisdottir S, Dauzats M, Thorne A, Langin D. Comparison of hormone-sensitive lipase activity in visceral and subcutaneous human adipose tissue. J Clin Endocrinol Metab, 1997 Dec;82(12):4162-6.
12. Watt MJ, Carey AL, Wolsk-Petersen E, Kraemer FB, Pedersen BK, Febbraio MA. Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion. Diabetologia, 2005 Jan;48(1):105-12.
13. Lynsgo D, Simonsen L, Bülow J (2002) Metabolic effects on interleukin-6 in human splanchnic and adipose tissue. J Physiol, 543:379–386.
14. Van Hall G, Steensberg A, Saacchetti M et al (2003) Interleukin-6 stimulates lipolysis and fat oxidation in humans. J Clin Endocrinol Metab, 88:3005–3010.
15. Jones DD, Ramsay TG, Hausman GJ, Martin RJ. Norepinephrine inhibits rat pre-adipocyte proliferation. Int J Obes Relat Metab Disord, 1992 May;16(5):349-54.
16. Kjaer M, Secher NH, Galbo H. Physical stress and catecholamine release. Baillieres Clin Endocrinol Metab, 1987 May;1(2):279-98. Review.
17. McMurray RG, Forsythe WA, Mar MH, Hardy CJ. Exercise intensity-related responses of beta-endorphin and catecholamines. Med Sci Sports Exerc, 1987 Dec;19(6):570-4.
18. Bangsbo J, Gollnick PD, Graham TE, Juel C, Kiens B, Mizuno M, Saltin B. Anaerobic energy production and O2 deficit-debt relationship during exhaustive exercise in humans. J Physiol, 1990 Mar;422:539-59.
19. Gaesser GA, Brooks GA. Metabolic bases of excess post-exercise oxygen consumption: a review. Med Sci Sports Exerc, 1984;16(1):29-43. Review.
20. Simonsen L, Bulow J, Madsen J, Christensen NJ. Thermogenic response to epinephrine in the forearm and abdominal subcutaneous adipose tissue. Am J Physiol, 1992 Nov;263(5 Pt 1):E850-5.
21. Lafontan M, Berlan M. Fat cell adrenergic receptors and the control of white and brown fat cell function. J Lipid Res, 1993 Jul;34(7):1057-91. Review.
22. Bougneres P, Stunff CL, Pecqueur C, Pinglier E, Adnot P, Ricquier D. In vivo resistance of lipolysis to epinephrine. A new feature of childhood onset obesity. J Clin Invest, 1997 Jun 1;99(11):2568-73.
23. Engfeldt P, Hellmer J, Wahrenberg H, Arner P. Effects of insulin on adrenoceptor binding and the rate of catecholamine-induced lipolysis in isolated human fat cells. J Biol Chem, 1988 Oct 25;263(30):15553-60.
24. Langfort J, Ploug T, Ihlemann J, Holm C, Galbo H. Stimulation of hormone-sensitive lipase activity by contractions in rat skeletal muscle. Biochem J, 2000 Oct 1;351(Pt 1):207-14.
25. Burleson MA Jr, O'Bryant HS, Stone MH, Collins MA, Triplett-McBride T. Effect of weight training exercise and treadmill exercise on post-exercise oxygen consumption. Med Sci Sports Exerc, 1998 Apr;30(4):518-22.
26. Watt MJ, Krustrup P, Secher NH, Saltin B, Pedersen BK, Febbraio MA. Glucose ingestion blunts hormone-sensitive lipase activity in contracting human skeletal muscle. Am J Physiol Endocrinol Metab, 2004 Jan;286(1):E144-50.
27. Watt MJ, Stellingwerff T, Heigenhauser GJ, Spriet LL. Effects of plasma adrenaline on hormone-sensitive lipase at rest and during moderate exercise in human skeletal muscle. J Physiol, 2003 Jul 1;550(Pt 1):325-32. Epub 2003 May 2.
28. Kjaer M, Howlett K, Langfort J, Zimmerman-Belsing T, Lorentsen J, Bulow J, Ihlemann J, Feldt-Rasmussen U, Galbo H. Adrenaline and glycogenolysis in skeletal muscle during exercise: a study in adrenalectomised humans. J Physiol, 2000 Oct 15;528 Pt 2:371-8.
29. Lafontan M, Berlan M. Fat cell alpha 2-adrenoceptors: the regulation of fat cell function and lipolysis. Endocr Rev, 1995 Dec;16(6):716-38. Review.
30. Stich V, De Glisezinski I, Crampes F, Hejnova J, Cottet-Emard JM, Galitzky J, Lafontan M, Riviere D, Berlan M. Activation of alpha(2)-adrenergic receptors impairs exercise-induced lipolysis in SCAT of obese subjects. Am J Physiol Regul Integr Comp Physiol, 2000 Aug;279(2):R499-504.
31. Prats C, Donsmark M, Qvortrup K, Londos C, Sztalryd C, Holm C, Galbo H, Ploug T. Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine. J Lipid Res, 2006 Nov;47(11):2392-9.
32. Amer P, Krieghblm E, Engieldt P, Bolinder J 1990 Adrenergic regulation of lipolysis in situ at rest and during exercise. J Clin Invest, 85:893-898
33. Talanian JL, Tunstall RJ, Watt MJ, Duong M, Perry CG, Steinberg GR, Kemp BE, Heigenhauser GJ, Spriet LL. Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise. Am J Physiol Regul Integr Comp Physiol, 2006 Oct;291(4):R1094-9.
34. Donsmark M, Langfort J, Holm C, Ploug T, Galbo H. Contractions activate hormone-sensitive lipase in rat muscle by protein kinase C and mitogen-activated protein kinase. J Physiol, 2003 Aug 1;550(Pt 3):845-54.
35. Arner P. Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Pract Res Clin Endocrinol Metab, 2005 Dec;19(4):471-82. Review.
36. Pritzlaff CJ, Wideman L, Blumer J, Jensen M, Abbott RD, Gaesser GA, Veldhuis JD, Weltman A. Catecholamine release, growth hormone secretion, and energy expenditure during exercise vs. recovery in men. J Appl Physiol, 2000 Sep;89(3):937-46.
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Research and Review 
