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Written by Robbie Durand
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Tuesday, 10 February 2009 |
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Page 4 of 5
NO Increases Fat-Burning Mitochondria And Increases Insulin Sensitivity
The mitochondrion is considered the powerhouse of the cell and is an important site for the fat oxidation, where the released chemical energy is for ATP synthesis. Therefore, mitochondria play a crucial role in regulating energy balance in the cell. Because NO stimulates the formation of metabolically active new mitochondria, the production of NO is of great interest regarding its effect on the treatment of obesity. Fat burning requires fat mobilization and then the delivery of fatty acids into the mitochondria of the muscle cell, where they can be burned as fuel. The more mitochondria a cell has, the greater the potential to burn more fat.
Other nutritional factors (e.g., omega-3 polyunsaturated fatty acids, Antioxidants and phytochemicals) that increase NO synthesis also will enhance fat oxidation, energy expenditure and insulin sensitivity. Insulin sensitivity is also of crucial importance for fat burning and increasing adipose tissue blood flow. Increasing insulin sensitivity increases fat burning, as adipose tissue fat metabolism is sensitive to insulin; any elevation in insulin due to insulin resistance results in reduced fat metabolism. Increasing insulin sensitivity will also increase blood flow in adipose tissue. Studies have shown that ATBF is directly related to insulin sensitivity in adipose tissue, regardless of bodyweight.30 Conversely, factors (e.g., high-fat diet, oxidative stress and protein malnutrition) that reduce NO synthesis will likely lead to reduced adipose tissue blood flow and increased fat mass. NO supplements may not only help you get a better pump in the gym, but will enhance adipose tissue blood flow and increase fat mobilization. Talk about a great added benefit!
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Research and Review 
