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Written by Robbie Durand
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Tuesday, 10 February 2009 |
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Page 5 of 5
Key Points:
• ANG II is a major vasoconstrictor of adipose tissue blood flow and inhibits fat mobilization.
• Reduced adipose tissue insulin sensitivity reduces adipose tissue blood flow and reduces fat burning.
• Nitric Oxide increases blood flow to not only muscle, but adipose tissue as well.
• Nitric Oxide, catecholamines and yohimbine all increase blood flow to adipose tissue and increase fat oxidation.
References:
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20. Ardilouze JL, Fielding BA, Currie JM, Frayn KN, Karpe F. Nitric Oxide and beta-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans. Circulation, 2004 Jan 6;109(1):47-52.
21. Galitzky J, Lafontan M, Nordenstrom J, et al. Role of vascular alpha-2 adrenoceptors in regulating lipid mobilization from human adipose tissue. J Clin Invest, 1993;91:1997–2003.
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24. Garcia-Villafranca, J., Guillen, A. & Castro, J. (2003) Involvement of Nitric Oxide/cyclic GMP signaling pathway in the regulation of fatty acid metabolism in rat hepatocytes. Biochem Pharmacol, 65:807-812.
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27. Fruhbeck, G. & Gomez-Ambrosi, G. (2001) Modulation of the leptin-induced white adipose tissue lipolysis by Nitric Oxide. Cell Signal, 13:827-833.
28. Fu WJ, Haynes TE, Kohli R, Hu J, Shi W, Spencer TE, et al. Dietary l-arginine supplementation reduces fat mass in Zucker diabetic fatty rats. J Nutr, 2005;135:714– 21.
29. Jobgen WS, Fried SK, Fu WJ, Meininger CJ, Wu G. Regulatory role for the arginine-Nitric Oxide pathway in metabolism of energy substrates. J Nutr Biochem, 2006 Sep;17(9):571-88. Epub 2006 Jan 9. Review.
30. Karpe F, Fielding BA, Ilic V, Macdonald IA, Summers LK, Frayn KN. Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity. Diabetes, 2002 Aug;51(8):2467-73.
31. Lucotti P, Setola E, Monti LD, Galluccio E, Costa S, Sandoli EP, Fermo I, Rabaiotti G, Gatti R, Piatti P. Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients. Am J Physiol Endocrinol Metab, 2006 Nov;291(5):E906-12.
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Research and Review 
