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UCP-3’s Role In Enhancing Fat Oxidation |
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Written by Robbie Durand
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Thursday, 12 February 2009 |
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Page 5 of 5
Leucine: The Ultimate Diet Amino Acid?
Leucine is an essential branched-chain amino acid that not only is a building block for protein synthesis, but is also a potent activator of the mammalian target of rapamycin (mTOR), a potent activator of may functions including protein synthesis, cell growth and metabolism. Branched-chain Amino Acids, especially leucine, have been speculated to play a key role in regulating metabolism. For example, Donato reported that leucine supplementation during caloric restriction results in more fat loss and improves protein synthesis in muscle.31 Get ready for more exciting news on leucine and fat loss. It was recently shown that doubling leucine intake while on a high-calorie diet substantially reduced diet-induced weight gain and improved glucose and cholesterol metabolism in mice. The use of L-leucine supplementation also resulted from increased resting energy expenditure associated with increased UCP-3 protein expression in skeletal muscle and in brown and white adipose tissues.32 So, leucine not only increases protein synthesis, but also reduces body fat by increasing UCP-3…can’t get much better than that! Leucine is the one supplement you can’t do without before a competition.
Key Points:
• UCP-3 is increased by growth hormone, thyroid, catecholamines and caffeine.
• UCP-3 is stimulated more by olive oil, palm oil and fish oil than saturated fats.
• UCP-3 is reduced by high carbohydrates and Fat Blockers.
• New research suggests that leucine stimulates UCP-3 expression in muscle.
References:
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Research and Review 
