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7-Keto Increases the Resting Metabolic Rate |
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Written by Anssi Manninen, MHS
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Tuesday, 07 August 2007 |
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3-acetyl-7-oxo-dehydroepiandrosterone,
or 7-keto, is a nonandrogenic derivative of DHEA. Promotional literature
suggests it increases you body's ability to burn calories. 7-keto appears to
induce enzymes in the mitochondria of cells that increase thermogenesis
(production of heat). A recent well-controlled study by Dr. Johen Zenkel and
colleagues tested the theory that 7-keto alone and in combination with calcium,
green tea extract, vitamin C, chromium nicotinate and Vitamin D3
("HUM5007") will increase the resting metabolic rate of overweight subjects
following a calorie-restricted diet. The subjects were randomized to three
seven-day treatment periods with 7-keto, "HUM5007" or placebo (fake
supplement). Researchers measured the resting metabolic rate by indirect
calorimetry at the beginning and end of each treatment period with a seven-day
"washout" between testing periods. Indirect calorimetry is a highly accurate
method of measuring energy expenditure. During the placebo treatment, the
resting metabolic rate decreased by 3.9 percent. However, the resting metabolic
rate actually increased by 1.4
percent and 3.4 percent during the 7-keto and "HUM5007" treatment periods,
respectively. These results are not meaningless; the subjects burned around 60
extra calories daily. "HUM5007" was only slightly more effective than 7-keto
alone (59+/-118 kcal/day vs. 21+/-115
kcal/day), suggesting that 7-keto was the main driving force behind the thermogenic
effect.
The author of
this article has no financial relationship with companies selling
7-keto-containing supplement.
Reference:
Zenk JL, et al, HUM5007, a novel combination of
thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each
increases the resting metabolic rate of overweight adults. J Nutr Biochem. 2007 Apr 4; [Epub ahead of print].
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