Leucine Enriched Essential Amino Acid Drink after Exercise Increases Muscle Growth Genes
If you are looking to pack
on some muscle size, you may want to consider adding an essential amino acid
drink enriched with leucine after exercise.
Researchers examined the anabolic effects of a leucine enriched
essential amino acid drink in young and old men after a bout a resistance
exercise. Researchers took muscle
biopsies to examine the expression anabolic and catabolic proteins. They found that even though the older and
younger men performed the same workout (70% of a 1-RM, 8 sets of 10 repetitions),
young and older men had different genes being turned on after exercise. They found:
- A protein called REDD2 (catabolic) which is a
negative regulator of mTOR (a key anabolic pathway) was
reduced in both younger and older men when they drank the leucine
enriched essential acid drink. This
means leucine turns off catabolic genes.
Good news for everyone!
- A protein called Rheb (anabolic) which a positive
regulator of mTOR was only increased in the young men who consumed
the leucine enriched essential acid drink.
This means younger men have greater anabolic genes being turned
on after exercise compared to older men.
- They also found increased in muscle IGF-1 levels
increased only in the young, while the older men had no changes and also
blunted satellite cell activity.
Older men have a blunted muscle hypertrophy response to exercise; a
decrease in IGF-1 seems to be a key cause.
The results of the study
suggest that an essential amino acid drink enriched with leucine which
was designed to maximally stimulate protein synthesis can benefit both older
and younger men after resistance exercise, but older men lose key anabolic
signaling pathways compared to younger men.
Drummond MJ, Miyazaki M, Dreyer HC, Pennings B, Dhanani S, Volpi E, Esser KA, Rasmussen BB. Expression of growth-related genes in young and old human skeletal muscle following an acute stimulation of protein synthesis. J Appl Physiol. 2008.