Written by Author L. Rea
10 October 2006

 

Q: Please help me! My boyfriend is currently using Winstrol, which I am injecting into him. Even though he says he knows a lot about it, I really don't think he does. My first question is, is it safe to inject every other day? I do what he asks me to do, but I'm a little uneasy about his knowledge of what he's doing. Also, is it normal for the injection area to become a little red and puffy? The first injection I gave him was quite red and puffy (it looked like a big mosquito bite) but the second and third weren't so bad because I massaged them for a little bit after injecting. If it's not normal, what do I do? Another question- he has me injecting him in a different area each time. Is that the correct thing to do? And what are the chances he's going to have "roid rage"? Please respond as soon as you can. As you can tell, I'm nervous about all this.
 

A: The use of any drug without proper medical guidance is always questionable and illegal to advise. However, I can give you some useful info.

Roid Rage and Proctology?

My experience both in the field and in the lab has been that ‘roid rage is nothing more than a justification for an asshole to be more of one. (I'm not suggesting that your boyfriend is less than a gentleman, of course). In the case of Winstrol (stanozolol), ‘roid rage is impossible even in theory. The reason is simply the structure. It is a DHT derivative (it has some secondary male characteristics such as increased libido, increased body hair growth and increased potential for hair loss and male aggression), but it is also a progestin (possessing female secondary sex characteristics). Women are only totally crazy during their periods, but usually more calm, otherwise. The two effects cancel each other so no ‘roid rage is possible- except due to being an asshole already.

Inflammation and Administration

The inflammation is due to the fact that Winstrol is an aqueous suspension. This means the drug itself has some very large crystals suspended in sterile water. When administered, drugs of this nature tend to act like salt in a wound, thus causing irritation and minor inflammation. Rubbing the site after administration is quite wise, actually. When the administration sites are alternated, the accumulative inflammation is reduced, as well.

            Stanozolol has a half-life of about 1-1.5 days, in truth. This means the drug would need to be administered at least EOD (every other day) to maintain a constant circulatory level.  Winstrol depot (injectable stanozolol) does not actually possess a classical ester half-life because it's non-esterified. Actually, the micro-crystals dissolve slowly in the tissue of administration. Once they've all dissolved, levels of the drug fall fairly rapidly, even though the drug is a c17-Alkylated structure. It's still an important factor, and thus included with a half-life of just over one day.


Q: What is your opinion of tren-only cycles? Also, what would be the best anti-estrogen choice?

 

A: Naturally, you are referring to trenbolone acetate or a black market version of Parabolan here. A trenbolone-only cycle has provided excellent results for many first time AAS (Anabolic/Androgenic Steroid) users with few, if any, negative side effects. However, since the drug is both a DHT derivative and progestin, there are some interactive Action/Reaction Factors to consider.

 

DHT Activity

DHT structures lead to a more vascular, harder appearance. This is often why some have believed that DHT derivatives such as Halotestin, Trenbolone and Primobolan are fat- burning as well. In truth, it's the increase in intracellular content and decrease in extracellular water retention that gives this aesthetic impression.


Progestin Activity

The progestin quality has some secondary estrogenic activity during high-dose prolonged employment. This is not a matter of aromatization of the trenbolone to estrogen or progesterone, but an action of the drug itself. Though estrogen receptor antagonists such as Nolvadex provide some small degree of anti-progesterone protection, the only truly effectual drugs for this purpose as of now are the abortion drug RU-486 and Faslodex, though most do not actually need either as an added part of a moderate-dose trenbolone protocol.

In regard to progestins, there is also a common increase in endogenous prolactin during and post-administration to consider. This is why some report impotence and gyno from more regular and prolonged use. Cabergoline or bromocriptine has effectively controlled this concern for those who have experienced it.

 

 

Q: The guy I work out with is on a cycle using GH and testosterone. He is getting bigger by the day and a little leaner, but I think his feet and hands are growing. He swears his dong is growing, too! Can this happen? I thought you were whatever size you're going to be by age 25!

 

A: Like most guys, your first interest is as to whether or not your friend has found a way to inject his way into phallic "believe it or not" history.

 

Synergy for Symmetry?

Though there's a small possibility your friend has not fully matured (physically) and is experiencing an appendage growth spurt (no pun intended) from an increase in androgens, it's more likely he is simply losing body fat in his pelvic region, thus allowing a greater amount of his "dong" to be exposed. When you think about it, I'm sure it will be obvious that an inch of fat in that area will result in an inch of appendage to be sequestered within. 

GH (growth hormone) is highly lipolytic (fat burning), as well as anabolic, to muscle and connective tissue. The administration of testosterone results in a blocking effect upon the fat synthesis enzymes. As a result, the two drugs combined have a synergistic effect upon muscular growth and of course, fat loss- which has multiple benefits, as you are now aware.

 

GH Use: An Odd Side Effect

Normally, your body controls its water table through the secretion of a hormone called aldosterone. Aldosterone triggers an increase in total sodium content resulting in a greater amount of extracellular (outside of the cells) water retention. This is often associated with aromatizing androgens (AAS that are susceptible to conversion to estrogens by the aromatase enzyme), but seldom is the resulting edema prominent solely in the feet and hands.

In the case of GH, some suffer a significant increase in water retention in these areas that gives them the appearance of being thicker and larger, though it is just water. Oddly enough there does not appear to be a dramatic increase in aldosterone production to account for this.

In most hard-core gyms, you can spot those using higher dosages of GH simply by noting a lack of vascularity on the backs of their hands and commonly untied shoes to allow for room. This is not to suggest that all who administer this hormone suffer this discomfort, of course. I have found several case sites of acromegaly (facial and skeletal malformation) as a result of hypersomatotropic (excess GH production by the pituitary gland) diseases but not one case site as a result of exogenous administration of GH, as of yet, though the potential certainly does exist.

 

Q: First I wish to say that your first book CME (Chemical Muscle Enhancement) has sparked a new fire in me and helped me to better understand AAS effects and usage. When can I get the second book, Building the Perfect Beast? I have many questions that I cannot find answers to in other places. I would like to add Long R-3 IGF-1 to the beginning of my upcoming cycle. I plan to take two weeks to decrease my body fat before I start the bulking phase. The reason for this is because of what you say about adipose tissue being a major site for aromatase enzyme activity and I don't want to have to be looking for a bra halfway through my cycle. Anyway, I will run Clen and T3 for the two weeks prior to my "bulker" and I have heard that LRIGF-1 will help to decrease fat while increasing LBM. My questions are: #1. Will LRIGF-1 help to reduce fat stores? How? #2. Will running LRIGF-1 right before a bulker (d-bol, test- e, nandrolone) take away from the AAS's effects? (Does this cause an increase in somatostatin and will it render any AAS induced GH to be lessened?)
 

A: Thank you for the reading my work. It's always nice to know that I have sparked thought in someone who wishes to progress.

 

Just Some Simple Answers

IGF-1 in any form increases insulin sensitivity, thus causing an improved portioning effect away from adipose (fat) store and toward lean tissue mass (like muscle). Due to this effect, most report a decrease in body fat percentage to some extent, but significant increases in lean mass during periods of higher calorie intake that is not excessive. Long R-3 IGF-1 itself does not possess any unique magic fat burning qualities beyond that of rIGF-1 or other such preparations with the exception of a prolonged period of activity.

In no way does the use of IGF-1 pre-AAS employment diminish results realized. In fact, there are many phases in which this is a correct procedure to ensure the greatest total lean muscle mass. Naturally, IGF-1 is quite synergistic with AAS administration allowing for greater progress than some expect.

GH (Growth Hormone) is a far better hormone for the purpose of adipose tissue reduction. This is due to a specific fragment of the GH molecule that interacts with receptors on fat cells. The result is that the fat cells give up the goods and an increase in fatty acid calorie expenditure occurs beyond that which is normal during calorie deficit periods. Additionally, GH prevents fat storage.

GH also allows an anti-catabolic environment to exist that spares lean tissue mass yet hinders fat synthesis and/or storage. (Pretty cool, huh?) In the presence of elevated thyroid hormone levels (specifically T-3 and T-2), an increase in uncoupling proteins occurs that acts to increase fat expenditure as heat. When this is done in a state of supraphysiological GH levels, the effect is compounded and again an increase in fat destruction results.

It is certainly a wise choice to decrease adipose tissue stores prior to any type of bulking phase. As such, there is a significant decrease in potential androgen aromatization to estrogens and less possibility of winning a wet T-Shirt contest, as well.

Oh, and the second book in the Chemical Muscle Enhancement series, Building the Perfect Beast, is now available.